World Journal of Acupuncture-Moxibustion

针灸在化疗诱发性恶心与呕吐防治中的治疗作用（英文）

Therapeutic roles of acupuncture in the treatment of chemotherapy induced nausea and vomiting

Chemotherapy-induced nausea and vomiting(CINV) remains one of the most disruptive complications during cancer treatment,often persisting despite standard antiemetic regimens.As clinical practice seeks supplementary strategies to enhance symptom control,acupuncture and moxibustion have emerged as promising adjunctive therapies.Existing trials and meta-analyses indicate their therapeutic potential,yet the neurobiological basis for these effects has not been fully elucidated.This study synthesizes current evidence to outline how acupuncture and moxibustion intervene in the peripheral and central pathways involved in CINV.Particular attention is given to their regulatory influence on vagal afferent signaling,gastrointestinal sensory pathways,and key neurotransmitter systems,such as 5-HT,SP, DA,and GABA,alongside modulation of brainstem nuclei and higher-order neural circuits implicated in emetic responses.The analysis also identifies procedural and methodological constraints in present clinical studies and highlights unresolved mechanistic questions.By integrating findings from neurophysiology and oncology-related symptom research,this review offers a foundation for more precise mechanistic investigations and for optimizing acupuncture-based interventions in CINV management.

Chemotherapy-induced nausea and vomiting(CINV) remains one of the most disruptive complications during cancer treatment,often persisting despite standard antiemetic regimens.As clinical practice seeks supplementary strategies to enhance symptom control,acupuncture and moxibustion have emerged as promising adjunctive therapies.Existing trials and meta-analyses indicate their therapeutic potential,yet the neurobiological basis for these effects has not been fully elucidated.This study synthesizes current evidence to outline how acupuncture and moxibustion intervene in the peripheral and central pathways involved in CINV.Particular attention is given to their regulatory influence on vagal afferent signaling,gastrointestinal sensory pathways,and key neurotransmitter systems,such as 5-HT,SP, DA,and GABA,alongside modulation of brainstem nuclei and higher-order neural circuits implicated in emetic responses.The analysis also identifies procedural and methodological constraints in present clinical studies and highlights unresolved mechanistic questions.By integrating findings from neurophysiology and oncology-related symptom research,this review offers a foundation for more precise mechanistic investigations and for optimizing acupuncture-based interventions in CINV management.

针刺治疗癌症相关症状及放化疗不良反应的随机对照试验报告质量评价（英文）

Overall reporting quality of acupuncture treatment for cancer-related symptoms and adverse effects of chemotherapy and radiotherapy

Objective:The objective of this study was to systematically evaluate the reporting quality of recent randomized controlled trials(RCTs) investigating the potential of acupuncture for the management of cancerrelated symptoms and chemotherapy-induced adverse effects.Methods:RCTs evaluating acupuncture for cancer-related symptoms and treatment-related adverse effects were retrieved from PubMed through December 31,2024.Data extraction and quality assessment were conducted using Excel spreadsheets,and the analysis was based on the CONSORT,STRICTA,and TIDieRPlacebo international reporting guidelines.Results:In total,129 studies were included,of which 126 were indexed in the Science Citation Index,encompassing 10,798 patients.Most studies were conducted in the United States and China and covered various types of cancer,including breast,colorectal,and head and neck cancer.The most commonly studied symptoms were pain,chemotherapy-induced peripheral neuropathy,and vomiting.Although most studies provided sufficient background information and clearly stated their research objectives and hypotheses,notable reporting deficiencies were observed in the randomization process,blinding implementation,sample size calculation,adverse events,acupuncture intervention details(e.g., needle depth and deqi response),adherence to placebo acupuncture,and environmental conditions.Conclusion:This study underscores deficiencies in the reporting quality of RCTs evaluating acupuncture for managing cancer-related symptoms,particularly regarding randomization,blinding,sample size calculations,and intervention details.Future investigations should adhere rigorously to international reporting guidelines,optimize study designs,and promote the standardization of acupuncture therapies to improve the transparency,reliability,and reproducibility of acupuncture RCTs,thereby supporting the evidencebased integration of acupuncture in cancer care.

Objective:The objective of this study was to systematically evaluate the reporting quality of recent randomized controlled trials(RCTs) investigating the potential of acupuncture for the management of cancerrelated symptoms and chemotherapy-induced adverse effects.Methods:RCTs evaluating acupuncture for cancer-related symptoms and treatment-related adverse effects were retrieved from PubMed through December 31,2024.Data extraction and quality assessment were conducted using Excel spreadsheets,and the analysis was based on the CONSORT,STRICTA,and TIDieRPlacebo international reporting guidelines.Results:In total,129 studies were included,of which 126 were indexed in the Science Citation Index,encompassing 10,798 patients.Most studies were conducted in the United States and China and covered various types of cancer,including breast,colorectal,and head and neck cancer.The most commonly studied symptoms were pain,chemotherapy-induced peripheral neuropathy,and vomiting.Although most studies provided sufficient background information and clearly stated their research objectives and hypotheses,notable reporting deficiencies were observed in the randomization process,blinding implementation,sample size calculation,adverse events,acupuncture intervention details(e.g., needle depth and deqi response),adherence to placebo acupuncture,and environmental conditions.Conclusion:This study underscores deficiencies in the reporting quality of RCTs evaluating acupuncture for managing cancer-related symptoms,particularly regarding randomization,blinding,sample size calculations,and intervention details.Future investigations should adhere rigorously to international reporting guidelines,optimize study designs,and promote the standardization of acupuncture therapies to improve the transparency,reliability,and reproducibility of acupuncture RCTs,thereby supporting the evidencebased integration of acupuncture in cancer care.

针刺治疗癌症相关症状及放化疗不良反应的随机对照试验报告质量评价国家自然科学基金82274640;国家自然科学基金82575280(英文)

Overall reporting quality of acupuncture treatment for cancer-related symptoms and adverse effects of chemotherapy and radiotherapy

目的：本研究旨在系统评估近年来关于针刺治疗癌症相关症状及化疗后不良反应的随机对照试验（RCT）报告质量。 方法：在PubMed上检索截止2024年12月关于针刺治疗癌症及其治疗相关不良反应的所有RCT。采用Excel表格进行数据提取和质量评估，基于CONSORT、STRICTA和TIDieR-Placebo三项国际报告指南进行分析。 结果：共纳入129篇文献，其中126篇为SCI收录，包含10789名患者。研究地点以美国，中国为主，癌症包括乳腺癌、结直肠癌、头颈癌等，疾病类型以疼痛、CIPN、恶心呕吐为主。大多数研究大部分研究提供了充分的背景、明确的研究目标和假设，但在随机化过程、盲法实施、样本量计算、不良反应、针刺干预的具体操作（如针刺深度、得气反应等）以及安慰剂针刺的依从性和环境描述方面存在报道缺失。 结论：本研究揭示了当前癌症相关症状管理中针刺RCT报告质量的不足，特别是在随机化、盲法、样本量计算和干预细节等方面的缺陷。未来的研究应严格遵循国际报告指南，优化研究设计，推动针刺疗法的标准化，以提高针刺RCT的透明度、可靠性和可重复性，为针刺在癌症管理中的循证医学发展提供支持。

Objective: The objective of this study was to systematically evaluate the reporting quality of recent randomized controlled trials (RCTs) investigating the potential of acupuncture for the management of cancer-related symptoms and chemotherapy-induced adverse effects. Methods: RCTs evaluating acupuncture for cancer-related symptoms and treatment-related adverse effects were retrieved from PubMed through December 31， 2024. Data extraction and quality assessment were conducted using Excel spreadsheets， and the analysis was based on the CONSORT， STRICTA， and TIDieR-Placebo international reporting guidelines. Results: In total， 129 studies were included， of which 126 were indexed in the Science Citation Index， encompassing 10，798 patients. Most studies were conducted in the United States and China and covered various types of cancer， including breast， colorectal， and head and neck cancer. The most commonly studied symptoms were pain， chemotherapy-induced peripheral neuropathy， and vomiting. Although most studies provided sufficient background information and clearly stated their research objectives and hypotheses， notable reporting deficiencies were observed in the randomization process， blinding implementation， sample size calculation， adverse events， acupuncture intervention details (e.g.， needle depth and deqi response)， adherence to placebo acupuncture， and environmental conditions. Conclusion: This study underscores deficiencies in the reporting quality of RCTs evaluating acupuncture for managing cancer-related symptoms， particularly regarding randomization， blinding， sample size calculations， and intervention details. Future investigations should adhere rigorously to international reporting guidelines， optimize study designs， and promote the standardization of acupuncture therapies to improve the transparency， reliability， and reproducibility of acupuncture RCTs， thereby supporting the evidence-based integration of acupuncture in cancer care.

从历史看未来——针灸标准发展脉络与展望

Looking at the future from a historical perspective: the development and prospects of acupuncture standards

<正>针灸是中医药学的重要组成部分，在中国已经有5千年的历史，从5世纪开始针灸已经开始走向世界，目前在196个国家得到传播应用。2010年11月联合国教科文组织将“中医针灸”列入人类非物质文化代表作名录，中国针灸已经成为世界人类的针灸。

针灸治疗神经根型颈椎病临床实践指南（英文）

Clinical practice guidelines of acupuncture-moxibustion for cervical spondylotic radiculopathy

在全面搜集相关文献证据基础上,按照证据质量与推荐强度分级系统(GRADE)方法,制定了《神经根型颈椎病针灸临床实践指南》,具体介绍了指南制定的目的、指南适用的疾病范围、针灸治疗神经根型颈椎病的原则、干预时机及不同针灸治疗方案等。

On the basis of relevant literature and evidence, Clinical Practice Guidelines of Acupuncture-moxibustion for Cervical Spondylotic Radiculopathy has been formulated according to the quality of evidences and by adopting the method of Grades of Recommendations Assessment, Development and Evaluation(GRADE), in which the objective of guidelines formulation, the scope of application of the guidelines, the principle of acupuncture-moxibustion treatment of cervical spondylotic radiculopathy, the time for intervention and different acupuncture-moxibustion regimens, etc. were specified.

针刺调节神经-内分泌-免疫网络研究进展（英文）

Research progress on regulations on nerve-endocrine-immune network by acupuncture

为从神经一內分泌-免疫(Nerve-endocrine-immune NEI)网络探寻针灸作用的机制,系统地分析了针刺调节NEI网络研究进展,研究目前存在的问题及未来发展趋势。发现NEI网络是人体维持自稳态的生物学基础,存在着传递信息的共同介质,针灸调节作用可能是激活了NEI网络或其共同介质。针灸学是注重整体调节的系统性医学,系统生物学与组学技术的不断发展,使从系统把握和整体认识针刺网络调节效应和机制成为新的发展趋势。

In order to explore the mechanism for the functions of acupuncture on nerve-endocrine-immune(NEI) network,authors carried out systematical analysis on the research progress of regulations on nerve-endocrine-immune network by acupuncture,and investigated current problems and future development tendency.It was found that NEI network was the biological basis for human body to maintain homeostasis and it utilized common medium for transmitting information,and the regulations by acupuncture may activate NEI network or its common medium.Science of acupuncture and moxibustion is the systematical science focusing on integrative regulations,and continuous development of system biology and omics techniques have enabled systematical assurance and comprehensive understanding of network regulatory effects and mechanisms by acupuncture to become new development tendencies.

针灸治疗神经根型颈椎病临床实践指南（英文）

Clinical practice guidelines of acupuncture-moxibustion for cervical spondylotic radiculopathy

在全面搜集相关文献证据基础上,按照证据质量与推荐强度分级系统(GRADE)方法,制定了《神经根型颈椎病针灸临床实践指南》,具体介绍了指南制定的目的、指南适用的疾病范围、针灸治疗神经根型颈椎病的原则、干预时机及不同针灸治疗方案等。

On the basis of relevant literature and evidence, Clinical Practice Guidelines of Acupuncture-moxibustion for Cervical Spondylotic Radiculopathy has been formulated according to the quality of evidences and by adopting the method of Grades of Recommendations Assessment, Development and Evaluation(GRADE), in which the objective of guidelines formulation, the scope of application of the guidelines, the principle of acupuncture-moxibustion treatment of cervical spondylotic radiculopathy, the time for intervention and different acupuncture-moxibustion regimens, etc. were specified.

针灸治疗肩周炎循证临床实践指南（英文）

Evidence-based clinical practice guidelines for acupuncture-moxibustion treatment of scapulohumeral periarthritis

全面检索文献,采纳国内外当前最佳证据,根据专家经验和患者价值观,借用证据质量与推荐强度分级系统(GRADE),结合全国范围专家的共识,制定本针灸临床实践指南,为针灸治疗肩周炎提供可靠证据,确保治疗的安全性和有效性。

The aim of this study was to establish clinical practice guidelines for acupuncture-moxibustion by retrieving relevant literature and adopting the best current national and international evidence, according to experts' experience and patients' values. This was achieved using the Grade of Recommendations Assessment, Development and Evaluation(GRADE) system combined with a wide range of national experts' consensus, in order to provide reliable evidence for acupuncture-moxibustion treatment of scapulohumeral periarthritis, and to ensure the safety and effectiveness of the treatment.